Though most celebrities head on Hot Ones with an entourage, some special snacks and an avowal to do their best at appearing relatable, Conan O'Brien is not most celebrities. 

The comedy legend recently dropped by the iconic interview series where he brought a heat of his own — a whole lot of bits, comic screaming, spitting and even keeping a “doctor” on call as he downed the spicy spread of wings.

"Come on, man, are we doing this or not?! Are we doing this or not?! What's the point of even being alive if we can't do this?!" He exclaimed after taking a bite — and a glug — of the show’s spiciest sauce, one clocking in at  2.693 Million Scovilles. 

From fan art to comparisons to former First Lady Nancy Reagan, here are 20 memes and reactions to O'Brien's instantly iconic Hot Ones spot.